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1

Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies

Nirmala Suman-Chauhan, Louise Webdale, David R. Hill, Geoffrey N. Woodruff

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1993

Language:

english

File:

PDF, 840 KB

english, 1993

2

ChemInform Abstract: PD 165929 - The First High Affinity Non-Peptide Neuromedin-B (NMB) Receptor Selective Antagonist.

J. M. EDEN, M. D. HALL, M. HIGGINBOTTOM, D. C. HORWELL, W. HOWSON, J. HUGHES, R. E. JORDAN, R. A. LEWTHWAITE, K. MARTIN, A. T. MCKNIGHT, J. C. O'TOOLE, R. D. PINNOCK, M. C. PRITCHARD, N. SUMAN-CHAUHAN

Journal:

Year:

1997

File:

PDF, 29 KB

1997

3

ChemInform Abstract: Design and Synthesis of Novel Nonpeptide CCK-B Receptor Antagonists.

J. K. PADIA, H. CHILVERS, P. DAUM, R. PINNOCK, N. SUMAN-CHAUHAN, L. WEBDALE, B. K. TRIVEDI

Journal:

Year:

1997

File:

PDF, 32 KB

1997

4

ChemInform Abstract: SAR Study of the Indole Moiety of CI-988, a Potent and Selective CCK-B Antagonist

C. E. AUGELLI-SZAFRAN, T. S. PURCHASE, B. D. ROTH, B. TAIT, B. K. TRIVEDI, M. WILSON, N. SUMAN-CHAUHAN, L. WEBDALE

Journal:

Year:

1997

File:

PDF, 29 KB

1997

5

ChemInform Abstract: Design and Synthesis of a Targeted Set of Aromatic Amino Acid Derivatives for Identification of New Lead Compounds (I)—(III).

D. C. HORWELL, C. O. KNEEN, M. C. PRITCHARD, G. S. RATCLIFFE, E. ROBERTS, N. SUMAN-CHAUHAN, K. STEINER, H. J. BETCHE

Journal:

Year:

1997

File:

PDF, 28 KB

1997

6

ChemInform Abstract: Design and Biological Evaluation of Non-Peptide Analogues of Omega-Conotoxin MVIIA.

Stefan Menzler, Jack A. Bikker, Nirmala Suman-Chauhan, David C. Horwell

Journal:

Year:

2000

File:

PDF, 33 KB

2000

7

The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists

P. Boden, J.M. Eden, J. Hodgson, D.C. Horwell, M.C. Pritchard, J. Raphy, N. Suman-Chauhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 222 KB

english, 1995

8

Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988

Corinne E. Augelli-Szafran, David C. Horwell, Clare Kneen, Daniel F. Ortwine, Martyn C. Pritchard, Terri S. Purchase, Bruce D. Roth, Bharat K. Trivedi, David Hill, Nirmala Suman-Chauhan, Louise Webdal

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 1.19 MB

english, 1996

9

Carboxylate bioisosteres of gabapentin

Carmen E. Burgos-Lepley, Lisa R. Thompson, Clare O. Kneen, Simon A. Osborne, Justin S. Bryans, Thomas Capiris, Nirmala Suman-Chauhan, David J. Dooley, Cindy M. Donovan, Mark J. Field, Mark G. Vartania

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 223 KB

english, 2006

10

The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design

P. Boden, J.M. Eden, J. Hodgson, D.C. Horwell, W. Howson, J. Hughes, A.T. McKnight, K. Meecham, M.C. Pritchard, J. Raphy, G.S. Ratcliffe, N. Suman-Chauhan, G.N. Woodruff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 374 KB

english, 1994

11

Synthesis of a potent and selective non-peptide CCK-B/gastrin receptor antagonist tritiated ligand.

D. Hill, D.C. Horwell, J.C. Hunter, C.O. Kneen, M.C. Pritchard, N. Suman-Chauhan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 228 KB

english, 1993

12

Design and synthesis of novel nonpeptide CCK-B receptor antagonists

J.K. Padia, H. Chilvers, P. Daum, R. Pinnock, N. Suman-Chauhan, L. webdale, B.K. Trivedi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 259 KB

english, 1997

13

SAR study of the indole moiety of CI-988, a potent and selective CCK-B antagonist

Corinne E. Augelli-Szafran, Terri S. Purchase, Bruce D. Roth, Bradley Tait, Bharat K. Trivedi, Michael Wilson, Nirmala Suman-Chauhan, Louise Webdale

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 276 KB

english, 1997

14

Design and synthesis of a targeted set of aromatic amino acid derivatives for identification of new lead compounds

D.C. Horwell, C.O. Kneen, M.C. Pritchard, G.S. Ratcliffe, E. Roberts, N. Suman-Chauhan, K. Steiner, H.J. Betche

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 235 KB

english, 1997

15

PD 176252 — The first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist

V. Ashwood, V. Brownhill, M. Higginbottom, D.C. Horwell, J. Hughes, R.A. Lewthwaite, A.T. McKnight, R.D. Pinnock, M.C. Pritchard, N. Suman-Chauhan, C. Webb, S.C. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 395 KB

english, 1998

16

Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA

Stefan Menzler, Jack A Bikker, Nirmala Suman-Chauhan, David C Horwell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 238 KB

english, 2000

17

Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin

Charles P. Taylor, Mark G. Vartanian, Yuen Po-Wai, Christopher Bigge, N. Suman-Chauhan, David R. Hill

Journal:

Epilepsy Research

Year:

1993

Language:

english

File:

PDF, 488 KB

english, 1993

18

PD 165929 — the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist

J.M. Eden, M.D. Hall, M. Higginbottom, D.C. Horwell, W. Howson, J. Hughes, R.E. Jordan, R.A. Lewthwaite, K. Martin, A.T. McKnight, J.C. O'Toole, R.D. Pinnock, M.C. Pritchard, N. Suman-Chauhan, S.C. Wi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 311 KB

english, 1996

19

Conformationally restricted analogues of the potent CCK-B antagonist CI-988

M. Higginbottom, D.R. Hill, D.C. Horwell, E. Mostafai, N. Suman-Chauhan, Edward Roberts

Journal:

Bioorganic & Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 939 KB

english, 1993

20

Activation of the cloned human NK3 receptor in Chinese Hamster Ovary cells characterized by the cellular acidification response using the Cytosensor microphysiometer

R E Jordan, D Smart, P Grimson, N Suman-Chauhan, A T McKnight

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 298 KB

english, 1998

21

The cholecystokinin-induced increase in intracellular calcium in AR42J cells is mediated by CCKB receptors linked to internal calcium stores

R.D. Pinnock, N. Suman-Chauhan, P. Daum, D.R. Hill, G.N. Woodruff

Journal:

Year:

1994

Language:

english

File:

PDF, 846 KB

english, 1994

22

Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies

David R. Hill, Nirmala Suman-Chauhan, Geoffrey N. Woodruff

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1993

Language:

english

File:

PDF, 735 KB

english, 1993

23

Characterisation of [125I][MePhe7]neurokinin B binding to tachykinin NK3 receptors: evidence for interspecies variance

Nirmala Suman-Chauhan, Pauline Grimson, Steve Guard, Zarina Madden, Fu-Zon Chung, Keith Watling, Robert Pinnock, Geoffrey Woodruff

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1994

Language:

english

File:

PDF, 693 KB

english, 1994

24

Characterization of tachykinin mediated increases in [Ca2+]i in Chinese hamster ovary cells expressing human tachykinin NK3 receptors

Robert D. Pinnock, Nirmala Suman-Chauhan, Fu-Zon Chung, Louise Webdale, Zarina Madden, David R. Hill, Geoffrey N. Woodruff

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1994

Language:

english

File:

PDF, 546 KB

english, 1994

25

Expression and characterisation of human and rat CRF2α receptors

Nirmala Suman-Chauhan, Pauline Carnell, Ruth Franks, Louise Webdale, Nicolas S Gee, Shaun McNulty, Christine J. Rossant, Don Van Leeuwen, Robert MacKenzie, Matthew D Hall

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 207 KB

english, 1999

26

Alanine scan and N-methyl amide derivatives of Ac-bombesin[7-14]. Development of a proposed binding conformation at the neuromedin B (NMB) and gastrin releasing peptide (GRP) receptors

DAVID C. HORWELL, WILLIAM HOWSON, DORICA NAYLOR, SIMON OSBORNE, ROBERT D. PINNOCK, GILES S. RATCLIFFE, NIRMALA SUMAN-CHAUHAN

Journal:

Chemical Biology & Drug Design

Year:

1996

Language:

english

File:

PDF, 2.16 MB

english, 1996

27

In vitro and in vivo inhibition of prolyl endopeptidase

John R. Atack, Nirmala Suman-Chauhan, Gerard Dawson, Janusz J. Kulagowski

Journal:

European Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 999 KB

english, 1991

28

Effects of tachykinins on inositol phospholipid hydrolysis in slices of hamster urinary bladder

D.R. Bristow, N.R. Curtis, N. Suman-Chauhan, K.J. Watling, B.J. Williams

Journal:

British Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 884 KB

english, 1987

29

Pharmacological characterization of tachykinin-stimulated inositol phospholipid hydrolysis in peripheral tissues

N. Suman-Chauhan, S. Guard, B.J. Williams, K.J. Watling

Journal:

British Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 979 KB

english, 1990

30

Inhibition of neuronal Ca2+ influx by gabapentin and pregabalin in the human neocortex

Klaus Fink, David J. Dooley, Wolfgang P. Meder, Nirmala Suman-Chauhan, Sandra Duffy, Hans Clusmann, Manfred Göthert

Journal:

Neuropharmacology

Year:

2002

Language:

english

File:

PDF, 162 KB

english, 2002

31

Activation of postsynaptic striatal dopamine receptors, monitored by efflux of cAMP in vivo

P.H. Hutson, N. Suman-Chauhan

Journal:

Neuropharmacology

Year:

1990

Language:

english

File:

PDF, 730 KB

english, 1990

32

The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret

Lakhbir Singh, Mark J Field, John Hughes, Be-Sheng Kuo, Nirmala Suman-Chauhan, Bishwa R Tuladhar, D.Scott Wright, Robert J Naylor

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 274 KB

english, 1997

33

Novel Nonpeptide CCK-B Antagonists: Design and Development of Quinazolinone Derivatives as Potent, Selective, and Orally Active CCK-B Antagonists 1

Padia, Janak K., Field, Mark, Hinton, Joanna, Meecham, Ken, Pablo, Julius, Pinnock, Rob, Roth, Bruce D., Singh, Lakhbir, Suman-Chauhan, Nirmala, Trivedi, Bharat K., Webdale, Louise

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 159 KB

english, 1998

34

Second Generation “Peptoid” CCK-B Receptor Antagonists: Identification and Development of N -(Adamantyloxycarbonyl)-α-methyl-( R )-tryptophan Derivative (CI-1015) with an Improved Pharmacokinetic Profile

Trivedi, Bharat K., Padia, Janak K., Holmes, Ann, Rose, Steven, Wright, D. Scott, Hinton, Joanna P., Pritchard, Martyn C., Eden, Jon M., Kneen, Clare, Webdale, Louise, Suman-Chauhan, Nirmala, Boden, P

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 236 KB

english, 1998

35

Cholecystokinin dipeptoid antagonists: design, synthesis, and anxiolytic profile of some novel CCK-A and CCK-B selective and mixed CCK-A/CCK-B antagonists

Boden, P. R., Higginbottom, M., Hill, D. R., Horwell, D. C., Hughes, J., Rees, D. C., Roberts, E., Singh, L., Suman-Chauhan, N., Woodruff, G. N.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.69 MB

english, 1993